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By Lisa M. Curtis PhD. Lisa M. Enigmas abound in the clinical care and research related to acute kidney injury AKI. Unfortunately, little conversion of research findings to changes in patient care has occurred.
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Sex and the Risk of AKI Following Cardio-thoracic Surgery: A Meta-Analysis

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Sex and the Risk of AKI Following Cardio-thoracic Surgery: A Meta-Analysis

Metrics details. Female sex has been included as a risk factor in models developed to predict the development of AKI. In contrast, a protective effect of female sex has been demonstrated in animal models of ischemic AKI. To further explore this issue, we performed a meta-analysis of AKI studies published between January, and April, and identified 83 studies reporting sex-stratified data on the incidence of hospital-associated AKI among nearly ,, patients. Twenty-eight studies 6,, patients utilized multivariate analysis to assess risk factors for hospital-associated AKI and provided sex-stratified ORs. Meta-analysis of this cohort showed that the risk of developing hospital-associated AKI was significantly greater in men than in women OR 1.
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Female sex reduces the risk of hospital-associated acute kidney injury: a meta-analysis

Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury AKI associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropathy. In contrast, female sex is reno-protective in animal models. In this context, we sought to examine the role of sex in hospital-associated acute kidney injury in greater detail. We utilized the Hospital Episode Statistics database to calculate the sex-stratified incidence of AKI requiring renal replacement therapy AKI-D among ,, hospital discharges reported for the years —
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Background and objectives Being awoman is awell established risk factor for the development of cardiothoracic surgery-associated AKI. In striking contrast, women are less likely to develop AKI associated with noncardiac surgical procedures than men. In an attempt to ascertain why being a woman might be protective for ischemic AKI after general surgery but deleterious in patients undergoing cardiothoracic surgery, we examined cardiothoracic surgery-associated AKI in greater detail.
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