Metrics details. The Norway lobster, Nephrops norvegicus , is economically important in European fisheries and is a key organism in local marine ecosystems. Despite multi-faceted scientific interest in this species, our current knowledge of genetic resources in this species remains very limited. Here, we generated a reference de novo transcriptome for N. Bioinformatic analyses were conducted to detect transcripts that were expressed exclusively in either males or females. Sixteen N.
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One source of this variability is sex. However, to date, there is little information in large cohorts on sex differences in the patterns of neurodegeneration. Overall, even though the two patient groups were matched for disease duration and severity, males demonstrated generally greater brain atrophy and disrupted connectivity. Local efficiency of white matter connectivity showed greater disruption in males in multiple regions such as basal ganglia, hippocampus, amygdala and thalamus. Most users should sign in with their email address. If you originally registered with a username please use that to sign in.
Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders
While genes with an excess of de novo mutations DNMs have been identified in children with neurodevelopmental disorders NDDs , few studies focus on DNM patterns where the sex of affected children is examined separately. Sex-biased genes are enriched in transcriptional processes and chromatin binding, primarily reside in the nucleus of cells, and have brain expression. By downsampling, we find that DNM gene discovery is greatest when studying affected females. Finally, directly comparing de novo allele counts in NDD-affected males and females identifies one replicated genome-wide significant gene DDX3X with locus-specific enrichment in females.
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